Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: yes

Primary TargetPorcn

Cell permeable: yes

General description

A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

5 mg in Glass bottle

Packaged under inert gas

Physical form

A 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2 (Cat. No. 681671) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Slight warming may be required upon initial thaw.

Warning

Toxicity: Standard Handling (A)