Lullaby® is the ideal siRNA transfection reagent for gene silencing. Relying on the TEE-technology, it has been successfully tested on numerous cell lines, reaching up to 90% gene silencing with high reproducibility and a very low toxicity. RNA interference is a powerful technique to shut down genes expression in cells and organisms. This silencing effect constitutes a very helpful tool to study gene’s function and a promising approach for new therapeutic treatments. Short RNA duplexes (siRNA: small interfering RNA, shRNA: small hairpin RNA and dsRNA: double strand RNA) are extremely selective by interacting and inducing the degradation of their specific mRNA targets and thereby inhibit the resulting protein production. Lullaby® siRNA transfection reagent introduces the siRNA duplexes in a variety of cells with a very high efficiency leading to exceptional knockdown effects with low doses of siRNA.

• Effective with very low doses of siRNA
• Minimised off-target effects
• Suitable for siRNA, shRNA, dsRNA, etc.
• Applicable to a broad range of cells
• Serum compatible and non toxic
• Straightforward protocol
• Perfect for all gene silencing applications: siRNA, shRNA, miRNA, dsRNA
• Suitable for all mammalian cells: cell lines, hard-to-transfect and primary cells