Not available outside of the UK & Ireland.

Application

Vincristine sulfate has been used:as a positive control in potato disc anti-tumor bioassayas a standard cytotoxic agentto treat cells for manipulation of the microtubule network

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

Biochem/physiol Actions

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.

General description

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.

Packaging

1, 5 mg in glass bottle

25 mg in poly bottle