Thrombin Receptor Activator Peptide 6, , >95% (HPLC)

Code: t1573-5mg D2-231

Not available outside of the UK & Ireland.

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro

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$531.44 5MG
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Not available outside of the UK & Ireland.

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 µM).

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

5 mg in glass bottle

assay>95% (HPLC)
formlyophilized
Gene Informationhuman ... F2R(2149)
InChI keyHAGOWCONESKMDW-FRSCJGFNSA-N
InChI1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
Quality Level200
SMILES stringCC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
solubility0.1% TFA: soluble, water: soluble
storage temp.−20°C
technique(s)cell culture | mammalian: suitable
UniProt accession no.P25116
Cas Number141136-83-6
This product has met the following criteria: