Not available outside of the UK & Ireland.

General description

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Other Notes

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

Physical form

Lyophilized from 0.2 µm-filtered solution in PBS.

Reconstitution

Reconstitute at 100 µg/mL in sterile PBS.