Not available outside of the UK & Ireland.

General description

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.

Other Notes

Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.

Physical form

Lyophilized from PBS with trehalose and Brij35.

Reconstitution

Reconstitute with 100 µL deionized water.