Not available outside of the UK & Ireland.

Analysis Note

This protein is not assayed for enzymatic activity.

Biochem/physiol Actions

Peptidyl arginine deiminases catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD3 modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. It converts arginine to citrulline in filaggrin at a faster rate than it does in trichohyalin. Together with the type I enzyme (PAD1), PAD3 play a role in terminal differentiation of the epidermis.

General description

Peptidyl arginine deiminase 3 (PAD3) is a member of the peptidyl arginine deiminase family of enzymes. It is expressed in the epithelium and hair follicles. The gene encoding this protein is localized on human chromosome 1p36.13.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles