Not available outside of the UK & Ireland.
Application
Study enzyme kinetics, and screen small molecule inhibitors for drug discovery and HTS applications.
General description
A fluorogenic, acetylated peptide substrate for HDAC′s. Based on residues 379-382 of p53, Arg-His-Lys-Lys, Ac, a site of regulatory acetylation by the p300 and CBP acetyltransferases, lysines 381, 382, 1-3, it is a suitable substrate for HDAC2, HDAC3, and HDAC6 tested so far.
Physical form
Supplied as a 5 mM solution in DMSO.
This product has met the following criteria: