Substance P acetate salt hydrate, >=95% (HPLC), powder

Code: s6883-5mg D2-231

Not available outside of the UK & Ireland.

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Application

Substance P acetate salt hydrate has been:used as a neurokinin 1 ...


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Not available outside of the UK & Ireland.

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Application

Substance P acetate salt hydrate has been:used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in miceadministered in central nucleus (ACE) in rat to study its positive reinforcing effectsused as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Substance P acetate salt hydrate has been used in competition binding assays.

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

General description

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

assay≥95% (HPLC)
colorwhite
formpowder
Gene Informationhuman ... TAC1(6863)
InChI keyVHKFRLDSEZYWAC-CIYRQLMPSA-N
InChI1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
mol wt1348 Da by calculation (Average Mass)
Quality Level200
SMILES string[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
solubility0.1 M acetic acid: 1 mg/mL
storage temp.−20°C
UniProt accession no.P20366
Code
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S6883-.5MG
Substance P acetate salt hydrate, >=95% (HPLC), powder

Unit:EACH
List Price: £55.80
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S6883-10MG
Substance P acetate salt hydrate, >=95% (HPLC), powder

Unit:10MG
List Price: £531.00
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S6883-1MG
Substance P acetate salt hydrate, >=95% (HPLC), powder

Unit:1MG
List Price: £81.00
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S6883-25MG
Substance P acetate salt hydrate, >=95% (HPLC), powder

Unit:25MG
List Price: £779.00
Source:List Price
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Cas Number137348-11-9
This product has met the following criteria: