Not available outside of the UK & Ireland.

Application

Myelin Basic Protein from guinea pig brain has been used as a component in emulsion to induce experimental autoimmune encephalitis (EAE).

Biochem/physiol Actions

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.

General description

Myelin basic protein (MBP), an important constituent of the myelin sheath of CNS (central nervous system). It is an autoimmunogen. MBP is mapped to human chromosome 18q.

Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.

Packaging

1, 5 mg in glass bottle

Principle

Used as a kinase substrate.

Quality

May contain traces of urea-glycine buffer salts.