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Biochem/physiol Actions

HIPK3 (homeodomain-interacting protein kinase 3) is a nuclear serine/threonine protein kinase and mainly controls death receptor signaling. HIPK3 is involved in the transcriptional corepression, cell differentiation, growth suppression and apoptosis. It is up-regulated in prostate cancer cells, resulting in increased resistance to Fas receptor-mediated apoptosis by disturbing association between FADD (fas-associated death domain) and caspase 8.

General description

HIPK3 (homeodomain-interacting protein kinase 3) is strongly expressed in the heart and muscle tissues. It is up-regulated in multidrug-resistant cells.

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Physical form

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.