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Biochem/physiol Actions

HIPK1 (homeodomain-interacting protein kinase 1) is responsible for phosphorylation of homeodomain transcription factors. HIPK1 interacts with DAXX (death domain-associated protein 6) and decreases its transcriptional repression activity. It is up-regulated in breast cancer cell lines and is suggested to be involved in tumorigenesis, partly by serine phosphorylation of p53.

General description

HIPK1 (homeodomain-interacting protein kinase 1) is a serine/threonine protein kinase. It belongs to the HIPK family. The protein is present in the nucleus.

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Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.