Not available outside of the UK & Ireland.

Analysis Note

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

Application

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Biochem/physiol Actions

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

General description

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.² It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

Physical form

Lyophilized from a 0.2 µm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 µg of bovine serum albumin per 1 µg of GDF-15.