S-(5-Adenosyl)-L-methionine p-toluenesulfonate salt,;, from yeast (L-methionine enriched), >=80% (HPLC), >=80% (spectrophotometric assay)

Code: a2408-25mg D2-231

Not available outside of the UK & Ireland.

Application

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.

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$86.49 25MG
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Not available outside of the UK & Ireland.

Application

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

Caution

This material is unstable at room temperature.

General description

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.

Packaging

25, 100, 500 mg in poly bottle

assay≥80% (spectrophotometric assay), ≥80% (HPLC)
biological sourcesynthetic (Organic)
colorwhite to off-white
compositionp-Toluenesulfonate content, 1.6-4.4 mol/mol
formpowder
InChI keyVHPOFDUCFKOUHV-XKGORWRGSA-N
InChI1S/C15H22N6O5S.C7H8O3S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10)/t7-,8+,10+,11+,14+,27?;/m0./s1
Quality Level200
shipped indry ice
SMILES stringO=C(O[H])[C@](N([H])[H])([H])C([H])([H])C([H])([H])[S@+](C([H])([H])[H])C([H])([H])[C@@]([C@](O[H])([H])[C@@]1([H])O[H])([H])O[C@]1([H])N2C3=C(N=C2[H])C(N([H])[H])=NC([H])=N3.O=S(C4=C([H])C([H])=C(C([H])([H])[H])C([H])=C4[H])([O-])=O
solubilityH2O: 100 mg/mL
storage temp.−20°C
Cas Number17176-17-9
This product has met the following criteria: