Not available outside of the UK & Ireland.

Application

Tetraethylammonium chloride (TEAC) has been used:used for inhibition of peroxynitrite induced relaxation in rat aorta ringsas a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neuronsfor the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Biochem/physiol Actions

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

Caution

moisture sensitive, handle under argon