Not available outside of the UK & Ireland.

General description

SRMS is a Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites that is involved in proliferation or differentiation of keratinocytes in the skin. SRMS functions as a rapid downstream signaling intermediate following calcium-induced differentiation in keratinocytes. SRMS constitutes a new family of non-receptor tyrosine kinases that may be redundant in function. SRMS can act either in the membrane or at the nucleus, and may change localization patterns depending on external stimuli.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.