Not available outside of the UK & Ireland.

General description

TAOK3 or TAO kinase 3 is a member of the serine/threonine-protein kinase family that inhibits the basal activity of Jun kinase and is negatively regulated by epidermal growth factor (EGF). Overexpression of TAOK3 may activate the ERK1/ERK2 and JNK/SAPK targets. TAOK3 is highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles