Not available outside of the UK & Ireland.

Biochem/physiol Actions

The transcription factor IIF (TFIIF) is composed of 58 kDa (RAP74) and 26 kDa (RAP34) subunits as a heterodimer, and was first identified through the ability to interact with immobilized RNA polymerase II. The Rap74 subunit of TFIIF can be phosphorylated by TAF250 both in vivo and in vitro. The RAP30 subunit of TFIIF contains two distinct regions with sequence similarity to E. coli s factors and can deliver RNA polymerase II to the promoter to support transcription initiation in the absence of RAP74.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.