Not available outside of the UK & Ireland.

Application

Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.

Biochem/physiol Actions

Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

General description

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

Other Notes

200 µL at 400 µM, or 80 nmol. Sold as 80 nmol

Physical form

Supplied in a TRIS-buffered solution.