Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophin family and GDNF family of ligands (GFL). GDNF plays a crucial role in the development, growth, and survival of neurons in particular midbrain dopaminergic neurons. GNDF is used to maintain neurons and cortical organoids and to differentiate dopaminergic neurons from human pluripotent stem cell-derived neural progenitors. GDNF also facilitates the differentiation of neural progenitors to astrocytes.

Recombinant human GDNF bioactive 30 kDa homodimer. This protein is animal origin-free (AOF), carrier protein-free, and tag-free to ensure its purity with exceptional lot-to-lot consistency.

• High purity GDNF (Uniprot: P39905)
• >98%, by SDS-PAGE quantitative densitometry
• 15.1 kDa monomer, 30.4 kDa (dimer)
• Expressed in E. coli
• Animal origin-free (AOF) and carrier protein-free
• Manufactured in Cambridge, UK
• Lyophilised from acetonitrile, TFA
• Resuspend in water at >100µg/mL, prepare single use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C