Activin A is a TGF–β family growth factor regulating embryonic development, cell proliferation, differentiation, and immune responses. Activin A is frequently used to maintain pluripotency in induced pluripotent and embryonic stem cell cultures. It is also used in many stem cell differentiation protocols, including endoderm lineage differentiation and further maturation into hepatocyte and pancreatic cells.

Recombinant human/mouse/rat/bovine/porcine activin A protein is a high-purity mature bioactive dimer of 26 kDa. It is animal origin-free, carrier protein-free, and tag-free to ensure its purity with exceptional lot-to-lot consistency. This protein has been rigorously benchmarked against other commercial sources and extensively validated for highly reproducible stem cell culture.

High purity mature bioactive dimer. Animal origin-free (AOF) and carrier-protein free (CF). Rigorously benchmarked against other commercial sources.

• Bioactive mature domain of recombinant human activin A protein, residues 311-426, (Uniprot: P08476)
• >98%, by SDS-PAGE quantitative densitometry
• 26 kDa (dimer)
• Expressed in E. coli
• Animal origin-free (AOF) and carrier protein-free.
• Manufactured in our Cambridge, UK laboratories
• Lyophilised from acetonitrile, TFA
• Resuspend in 10mM HCl at >100µg/mL (provided with protein and free of charge), prepare single use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C