Not available outside of the UK & Ireland.

Application

Myelin Basic Protein (MBP) bovine has been used in following studies:In vitro methylation reaction.Myelin basic protein is used as a substrate in in vitro immunoprecipitation-kinase assay to measure Cds1 (the S-phase-specific checkpoint effector kinase) activity.It is used to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays.

Used as a kinase substrate.

Biochem/physiol Actions

Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis. Major structural protein of CNS myelin

Major structural protein of CNS myelin

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP functions as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Packaging

1, 5, 25 mg in glass bottle

Quality

May contain traces of urea-glycine buffer salts.