MEKK2, active, GST tagged human, PRECISIO Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Code: m0324-10ug D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

MEKK2 (also known as mitogen-activated protein kinase (MAPK) kinase kinase 2) is a major upstream activator of the JNK/MAPK cascade. MEKK2 can mediate...


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$542.10 10UG

Not available outside of the UK & Ireland.

Biochem/physiol Actions

MEKK2 (also known as mitogen-activated protein kinase (MAPK) kinase kinase 2) is a major upstream activator of the JNK/MAPK cascade. MEKK2 can mediate in vitro phosphorylation of MKK4 and MKK7 which are key MAPKs that activate JNK. In addition, MEKK2 immunoprecipitates activated JUN in an IL1-dependent manner. Rheumatoid arthritis and osteoarthritis synovial tissues show high levels of MEKK2 indicating that it may be an important activator of the JNK pathway in arthritis. Endogenous MEKK2 is localized mainly in the cytosol of unstimulated cells.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

assay≥70% (SDS-PAGE)
formbuffered aqueous glycerol solution
Gene Informationhuman ... MAP3K2(10746)
mol wt~115 kDa
product linePRECISIO® Kinase
Quality Level200
recombinantexpressed in baculovirus infected Sf9 cells
shipped indry ice
specific activity192-260 nmol/min·mg
storage temp.−70°C
UniProt accession no.Q9Y2U5
This product has met the following criteria: