Not available outside of the UK & Ireland.

Biochem/physiol Actions

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It is secreted by monocytes and lymphocytes. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.

Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Other Notes

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

Physical form

Solution in 0.2 µm filtered phosphate buffered saline, pH 7.4.