Gly-Arg-Gly-Asp-Ser-Pro-Lys, >=97% (HPLC)

Code: g1269-1mg D2-231

Not available outside of the UK & Ireland.

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

Application

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-as a blocking peptide to inhi...


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$210.13 1MG
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Not available outside of the UK & Ireland.

Amino Acid Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Lys

Application

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-as a blocking peptide to inhibit integrin-fibronectin bindingin adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesionfor incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)for the preparation of RGD.Flt23k.NR nanoparticlesto determine the involvement of RGD-integrin bonding in cell adhesion process

Biochem/physiol Actions

Fibronectin analog that binds to integrins.

General description

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

assay≥97% (HPLC)
biological sourcehuman
formpowder
Gene Informationhuman ... ITGA2B(3674), ITGAV(3685)
InChI keyZRVZOBGMZWVJOS-VMXHOPILSA-N
InChI1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
Quality Level200
SMILES stringNCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
storage temp.−20°C
technique(s)blocking: suitable, ligand binding assay: suitable
Cas Number111119-28-9
This product has met the following criteria: