Not available outside of the UK & Ireland.

Biochem/physiol Actions

Spontaneously undergoes autoprocessing to yield the subunits associated to form the active enzyme.

Useful in screening caspase inhibitors, studying enzyme regulation, determining specificity of caspase substrates, or as a positive control in caspase activity assays.

Cleaves the substrates consisting of consensus sequence VEID.

Physical form

Contains 0.052% ammonium sulfate, 0.158% Tris−HCl, 0.76% sodium chloride.

Unit Definition

One unit will hydrolyze 1 nmol of the caspase substrate VEID-pNA to VEID and p-nitroaniline per hour at pH 7.2 at 37 °C.