Not available outside of the UK & Ireland.

Application

Apo A-II constitutes ~20% of the protein moiety of high density lipoprotein (HDL).

Biochem/physiol Actions

Unlike Apo A-I, Apo A-II possesses no activating properties for lectin-cholesterol acyltransferase (LCAT). Furthermore, it was found that Apo A-II inhibits the activation of LCAT by Apo A-I.

General description

Forms dimers in aqueous solutions with an association constant of 5 × 10⁴ M^-1. The association is accompanied by an enhancement of ~35% in α-helical content.

Physical form

Solution in 10 mM ammonium bicarbonate.