Not available outside of the UK & Ireland.

Application

n-dodecyl-β-D-maltoside (DDM) has been used to solubilize mitochondrialextracts of fibroblasts to perform one-dimensional blue-native PAGE (BN-PAGE) analysis for assembled oxidative phosphorylation (OXPHOS) complexes.

Biochem/physiol Actions

n-dodecyl-β-D-maltoside (DDM) exhibits biocompatibility and biodegradability. It serves as a facilitator of electron transfer in order to decrease the oxidation potential of 3,4-ethylenedioxythiophene (EDOT). It can also increase the solubility of EDOT in aqueous solution.

General description

n-dodecyl-β-D-maltoside (DDM) is a sugar-based surfactant.

DDM is the most widely used detergent for the isolation and purification of GPCR’;s. In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form.

Packaging

20 mL Clear Glass Screw Cap Vial (850520P-1g)

30 mL Amber Wide Mouth Screw Cap Glass Bottle (850520P-5g)

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850520P-25g)