Not available outside of the UK & Ireland.

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached Protocolfor details.

Biochem/physiol Actions

CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) is part of major histocompatibility complex (MHC) class II and its function is associated with antigen presentation. Upregulation of the CD74 gene is observed cancer including breast cancer and it is known to promote to metastasis. CD74 also serves as a cytokine receptor in immune and epithelial cells. It induces cellular processes such as cell proliferation, migration and survival pathways.

General description

The CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) gene encodes for a type II transmembrane protein and is expressed by antigen presenting cells such as monocytes, B cells, macrophages and dendritic cells. The CD74 gene is mapped to human chromosome 5q33.1.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.