Not available outside of the UK & Ireland.
Application
For research use only. Not for use in diagnostic procedures.Mouse Shh-N ELISA Kit has been used to measure serum sonic hedgehog (Shh) level.
Biochem/physiol Actions
Sonic hedgehog (Shh) is a secreted glycoprotein involved in embryonic morphogenic development of several tissues. It has a role in fracture healing and regeneration. In the canonical pathway, the protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer. Shh plays a vital role in axon growth and guidance throughout the brain development. Shh stimulates neurite outgrowth by overcoming neurite growth inhibitory environment associated with glial scar.
General description
The Mouse Shh-N (Sonic Hedgehog N Terminus) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of mouse Shh-N in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Mouse Sonic Hedgehog (N-terminus)
Other Notes
A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.
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