Not available outside of the UK & Ireland.

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Glial cell derived neurotrophic factor (GDNF) is a neurotrophic factor involved in dopaminergic and neurodevelopment. It plays a vital role in self-renewal of stem cells. In addition, GDNF also facilitates differentiation of chained undifferentiated spermatogonia. GDNF with its receptors, activates various signaling pathways essential for maintaining cellular homeostasis. Mutated gene is associated with the development of schizophrenia. GDNF is a potential target for treating Parkinson′s disease.

General description

Glial cell derived neurotrophic factor (GDNF) is encoded by the gene mapped to human chromosome 5p14.1−q13.3. It belongs to the transforming growth factor β (TGF-β) superfamily. GDNF is abundantly found in gliomas.

Immunogen

Recombinant Human GDNF

Other Notes

A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.