Not available outside of the UK & Ireland.

Application

For research use only. Not for use in diagnostic procedures.Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

M-CSF (colony stimulating factor 1) plays a major role in the immune response, bone metabolism and the development of some cancers. It modulates macrophage survival, proliferation, differentiation and chemotaxis.

General description

The Human MCSF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MCSF in serum, plasma, cell culture supernatants and urine.

M-CSF (colony stimulating factor 1) is a pleiotropic macrophage growth factor. It has a signal peptide, a 149-amino acid receptor-binding domain, a variable spacer region and a transmembrane region with a cytoplasmic tail. The human M-CSF receptor is a 972-amino acid glycosylated protein which consist of an extracellular region made of five immunoglobulin-like domains (D1–D5), a transmembrane region and an intracellular autocatalytic kinase domain. This gene is mapped to human chromosome p13-p21.

Immunogen

Recombinant Human MCSF

Other Notes

A sample Certificate of Analysis is available for this product.Please type the word sample in the text box provided for lot number.