Not available outside of the UK & Ireland.

Biochem/physiol Actions

1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α₁-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α₁-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

Caution

Aqueous stock solutions containing 0.01% NaN₃ are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

Packaging

5, 25 mg in glass bottle

Preparation Note

Chromatographically prepared and partially purified.