Not available outside of the UK & Ireland.

Application

Guanosine 5′-triphosphate sodium salt solution has been used:for reconstituting transducin during purification of transducin.as a compnent of the 3.3X loading buffer to assemble 32P-miR-31—3xFLAG-AGO2 complexesas a component of the nucleotide substrate mix to evaluate the hydrolytic activity of MutT homolog 1 (MTH1) on methylated nucleoside triphosphatesin DNA-dependent RNA polymerase transcription

Biochem/physiol Actions

Guanosine 5′-triphosphate (GTP) forms nearly 25% of the total nucleotide triphosphate pool and is a nucleotide anion. It participates in several biological functions such as cell signaling by activation of GTP-binding proteins, RNA and protein synthesis, and production of cyclic guanosine monophosphate (cGMP), a secondary messenger. GTP also participates in the production of stringent alarmone.