Not available outside of the UK & Ireland.

Application

AMP-PNP has been used in the preparation of nucleotide solutions, two-motor fluorescence assay, preparation of flow-cells with kinesin and cascade binding assays.

AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase. AMP-PNP has been used for two-motor fluorescence assay.

Features and Benefits

Contents88% AMP-PNP (from N), 4.5% lithium, 6% water

General description

AMP-PNP(adenylyl-imidodiphosphate) is an artificial substrate of enzyme, adenylate cyclase. Adenylate cyclase helps to hydrolyze adenylyl-imidodiphosphate slowly than ATP.

AMP-PNP (adenylyl-imidodiphosphate) is a non-hydrolysable analogue of ATP. It inhibits fast axonal transport and facilitates the interaction between membranous organelles and microtubules.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Quality

Contaminants: ≤1.5% Pi , ﹤0.1% ATP (enzymatically)

Storage and Stability

Store at -15–-25 °C. (Store dry!)