Not available outside of the UK & Ireland.

Application

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.

General description

•Polymer architecture: Dendron•Generation: 3•Core functional group: Boc-protected amine•End group functionality: Carboxylic acid•No. surface groups: 8•Calculated mol. wt.: 1978.82 g/mol•Boc: tert-Butyloxycarbonyl•Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Polyester bis-MPA dendron (8 carboxyl, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.