Not available outside of the UK & Ireland.

Application

Cytochrome P450 3A4 human has been used in circular dichroism analysis.

Biochem/physiol Actions

Cytochrome P450 3A4 (CYP3A4) is one of the isoform of cytochrome P450 (P450s). Cytochrome P450s (P450s) play a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.

General description

Supplied as purified soluble proteins, rather than microsomal preparations.

Other Notes

Visit our drug metabolism resources: www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/cell-signaling-enzymes/xenobiotics.html

Unit Definition

One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.