Not available outside of the UK & Ireland.

Application

FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Biochem/physiol Actions

FMO′s are responsible for catalyzing the oxygenation of a variety of xenobiotic and drug compounds including environmental pollutants and carcinogens, which demonstrate a nucleophilic nitrogen, sulfur, selenium, and phosphorous-containing moiety associated with their respective oxides. These enzymes are classified as Phase I or oxidative drug metabolism enzymes. FMO5 is the only FMO isoform expressed in both adult and fetal human liver.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Unit Definition

methyl p-tolyl sulfide oxidase activity: One unit will catalyze the production of 1.0 picomole of methyl p-tolyl sulfoxide.