Not available outside of the UK & Ireland.

Application

Polymyxin acylase, from Pseudomonas sp., is a N-myristoyl cleaving enzyme that has been used to determine the N-myristoyl peptide sequence and may be useful in cancer research since it has antitumor activity against murine and human tumor cells .

Biochem/physiol Actions

Polymyxin acylase, from Pseudomonas sp. deacylates polymyxin group antibiotics and long-chain fatty acyl groups of proteins. Polymyxin acylase has an affinity for long-chain fatty acyl proteins in human carcinoma cells .

Quality

Crude actone powder;

Unit Definition

One unit will hydrolyze 1 µmole of N-octanoyl-5-aminovaleric acid per min at pH 8.0 at 37°C.