Not available outside of the UK & Ireland.

Application

S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .

Biochem/physiol Actions

MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation .

Legal Information

TWEEN is a registered trademark of Croda International PLC

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween^®-20, 10% glycerol,and 3 mM DTT.

Physical properties

N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.