Not available outside of the UK & Ireland.

Application

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride has been used:as a fluorogenic substrate in actinidin inhibition assayas a kallikrein substrateas a trypsin substrate for fluorometric assayas a cathepsin-L substrate

Biochem/physiol Actions

Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) proteolytic lysis by proteases leads to the liberation of AMC resulting in increased fluorescence in the enzymatic reaction.

General description

Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) is a peptidomimetic substrate for papainand other enzymes such as cathepsin K. It is also a fluorogenic synthetic peptide for the enzymes cathepsins L and B.

Packaging

100 mg in glass bottle

25 mg in glass insert

Substrates

A fluorogenic substrate for plasma kallikrein.