Not available outside of the UK & Ireland.

Application

Methylglyoxal solution has been used:to assess glyoxalase 1 (GLO1) enzymatic activityas an advanced glycation end (AGE) forming agent for the preparation of albumin in vitroto regulate anxiety like behavior in miceto induce peritoneal fibrosis in ratsto study the chromatographic retention characteristics of organic chemicals and metal DNA adductsfor intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

General description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.