Not available outside of the UK & Ireland.

Application

GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca²⁺ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca²⁺ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 µM.

Quantity

For PKC inhibition, typically used at a concentration of 0.1-10 µM.