Not available outside of the UK & Ireland.

Application

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.

1,10-Phenanthroline monohydrate has been used:as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cellsas a negative control in in situ zymography of mice heart samplesin in vitro resveratrol chelation and reducing activities assays to chelate iron

Biochem/physiol Actions

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

General description

Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.

Packaging

1, 5, 25, 100 g in poly bottle