Cyclosporin A, >=98.5% (HPLC) , Powder, for Immunosuppressive Studies

Code: 30024-25mg D2-231

Not available outside of the UK & Ireland.

Application

Cyclosporin A is used for immunosuppressive studies .

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive...


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Your Price
£108.00 25MG
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Not available outside of the UK & Ireland.

Application

Cyclosporin A is used for immunosuppressive studies .

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

General description

Chemical structure: peptide

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.

Packaging

25, 100 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

antibiotic activity spectrumfungi
assay97.0-101.5% (on dried basis)
colorwhite to off-white
formpowder
Gene Informationhuman ... PPIA(5478)
InChI keyPMATZTZNYRCHOR-CGLBZJNRSA-N
InChI1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
mode of actionenzyme | inhibits
Quality Level200
SMILES stringCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
30024-100MG
Cyclosporin A, >=98.5% (TLC)

Unit:100MG
List Price: £332.00
Source:List Price
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Cas Number59865-13-3
This product has met the following criteria: