Vivaspin sample concentrators are designed for fast, nondenaturing concentration of biological samples by membrane ultrafiltration. Up to 30-fold concentration of the sample can be achieved with recovery of the target molecule typically exceeding 95%. The entire process is performed in a single tube with an upper compartment containing sample and lower compartment separated by a semipermeable membrane with a molecular weight cut-off (MWCO) selected by the user. Centrifugation is applied to force solvent through the membrane, leaving a more concentrated sample in the upper chamber.

Vivaspin sample concentrators cater for sample volumes from 100 µl to 20 ml, with a range of molecular weight cutoff values from Mr 3 000 to 100 000. For maximum recovery, select a MWCO at least 50% smaller than the molecular size of the species of interest.

• One-step sample concentration in a single tube for minimal sample handling and reduced sample loss.
• Patented dead-stop technology, which ensures that samples cannot be concentrated to dryness and enables direct concentrate recovery
• Vertical polyethersulfone membrane minimises membrane blockage and tolerates high flow rates.
• Compatible pH range is from pH 1 to 9.
• Easy, contact-free storage by reverse spinning the concentrate into the recovery cap