Not available outside of the UK & Ireland.

Application

Choline chloride has been used:as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cellsfor choline standard curve generation for quantifying phospholipase D (PLD) activityas a component of slice solution for the dissection of entorhinal-hippocampal brain slices

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

General description

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.

Packaging

1 kg in poly drum

100, 500 g in poly bottle

Substrates

Choline acetyltransferase substrate