Insulin solution from bovine pancreas, 10 mg/mL insulin in 25 mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

Code: i0516-5ml D2-231

Not available outside of the UK & Ireland.

Application

Insulin solution from bovine pancreas has been used:to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth fac...


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£144.00 5ML
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Not available outside of the UK & Ireland.

Application

Insulin solution from bovine pancreas has been used:to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifersto study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explantsto study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro

Biochem/physiol Actions

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.

Physical form

stable 2-8 °C

concentration10 mg/mL insulin in 25 mM HEPES, pH 8.2
formsolution
Gene Informationbovine ... INS(280829)cow ... INS(280829)
impuritiesendotoxin, tested
InChI keyXYPANFGXFLOTDK-CJLNJPJHSA-N
InChI1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1
pH7.9-8.5
product lineBioReagent
Quality Level400
shipped inambient
sterilitysterile-filtered
storage temp.2-8°C
technique(s)cell culture | mammalian: suitable
UniProt accession no.P01317
Cas Number11070-73-8
Pack5ML
This product has met the following criteria: