Nikkomycin Z from Streptomyces tendae, >=90% (HPLC)

Code: n8028-5mg D2-231

Not available outside of the UK & Ireland.

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human...


read more

Your Price
$307.40 5MG
REQUEST

Not available outside of the UK & Ireland.

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure.

Biochem/physiol Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

General description

Chemical structure: peptidyl nucleoside

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Packaging

5 mg in glass bottle

antibiotic activity spectrumfungi
assay≥90% (HPLC)
formpowder
InChI keyWWJFFVUVFNBJTN-JKEIIPFCSA-N
InChI1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12+,13-,14-,15+,16+,18+/m0/s1
mode of actioncell wall synthesis | interferes, enzyme | inhibits
Quality Level200
SMILES stringC[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3
solubilityH2O: soluble 5 mg/mL
storage temp.2-8°C
Cas Number59456-70-1
This product has met the following criteria: