Not available outside of the UK & Ireland.

Application

Novobiocin, an inhibitor of Hsp90, is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Biochem/physiol Actions

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.Antimicrobial spectrum: Gram-positive bacterial.

General description

Chemical structure: coumarin-glycoside

Other Notes

Stored in frozen aliquots,Keep container tightly closed in a dry and well-ventilated place.Light sensitive

Packaging

1, 5, 25, 100 g in glass bottle